It has been reported to control cell behaviors via patterns, but the control of cell nucleus shape was rarely reported and the severe deformation was unexpected. The research of Prof. Ding group revealed that cell nucleus could be severely deformed via micropillar patterns.

Subsequently, they designed different patterns and realized different kinds of control, including crosses, ball with hillock, dumb-bell shape, squares and so on. This paper has been published in Biomaterials (IF=7.882)

Control of cell nucleus shapes via micropillar patterns

Zhen Pan, Ce Yan, Rong Peng, Yingchun Zhao, Yao He, and Jiandong Ding*, Biomaterials, 33, 1730-1735 (2012)

       丁建東課題組還證實➕，這些細胞核嚴重自我變形的骨髓基質幹細胞不僅仍然具有活力🕟，而且保持著增殖和被誘導成骨分化的能力👨🏻‍🏫。有關核變形的生物學意義以及這一發現對於新型生物材料設計的作用仍待探索。